"Cardfight!! Vanguard: Lock on Victory!!" is the second Cardfight!! Vanguard video game to be released on the Nintendo 3DS.
- Includes cards from the 3rd Season.
- Players may choose 1 from 10 exclusive characters (6 from "Ride to Victory!!" and 4 new from this game) at the start the game, as well as change it during the storyline. The 4 new characters are the following:
- Kazuya (male).
- Erika (female).
- Subaru (male).
- Rin (female).
- Players can also clothe its character with the corresponding school uniform (Hitsue High, Fukuhara High, or Miyaji Academy).
- Players will be able to start the game using one of the available Trial Decks, including new exclusive decks from the game.
- Angel Feather: "Aid of the Angels".
- Tachikaze: "Supreme Dragon of the Ancient Past".
- Murakumo: "Spikes of the Hidden Army".
- Dark Irregulars: "Twilit Superhuman".
- Pale Moon: "Circus of the Moonlit Night".
- Spike Brothers: "Lawless Noisemakers".
- Granblue: "Attack of the Ghost Ship".
- Megacolony: "Indomitable Mutant Insects".
- Great Nature: "The Wisdom of Beasts".
- Neo Nectar: "Eternity of Nature".